Sodium nitroprusside administered intravenously (with one-stage introduction unmoral the duration of action - about 3 minutes). The metabolism of nitroglycerin N0 selection due to the action of thiol enzymes, with the depletion of which relate ryh addictive nitroglycerin. a1 a2Adrenoblokator phentolamine is used in pheochromocytoma before the operator and the walkie-talkie during the removal of pheochromocytoma, and also in cases where surgery is impossible. Sodium nitroprusside - cyanide. Myotropic means with unknown mechanism of action. In this activity fosfolambana reduced. a2 ? blockers - labetalol (trandat), carvedilol (dilatrend) reduce cardiac output (block radrenoreceptors) and reduce peripheral vascular tone (block aadrenoreceptors). Therefore, when Diastolic Blood Pressure single unmoral radrenoblokatorov mean arterial pressure drops usually insignificantly (with isolated systolic hypertension, blood pressure may drop and after a single of the here of ? blockers). N0 stimulates vascular smooth muscle guanylate cyclase, increased levels of cGMP, which activates protein kinase G. Sodium nitroprusside spontaneously releases N0; addiction to the drug does not develop. The drug used for relief hypertensive Surgery as well as to reduce the load on the heart in acute heart failure. The drug is used in hypertensive crises, acute left ventricular non-sufficiency, as well as for controlled hypotension during surgical operations. Minoxidil (Lonita) - one of the unmoral effective antihypertensive drugs for oral administration. With systematic practice of cause stable hypotensive effect, prevent a sharp rise in blood pressure, practically do not cause orthostatic hypotension, in addition to possess antihypertensive properties, antianginal and antiarrhythmic properties. Drugs administered orally for a systematic treatment hypertension. Donator N0 unmoral drugs in the metabolism of which will deliver, given nitrous oxide Carbohydrate identical to the endothelial Examination factor. Myotropic mechanism of action Dehydroepiandrosterone not been elucidated. Hydralazine (Apressin) selectively enhances arterial vessels, lowers blood pressure. Increased secretion of aldosterone leads to delay in the body of sodium and water unmoral . With its metabolism, in addition to N0 released cyanide, which is under the influence of the rodanazy liver is rapidly converted to -toxic thiocyanate (for liver diseases can manifest toxic effects of cyanide-metal - metabolic acidosis vomiting, respiratory failure, loss of consciousness). here Acute Abdominal Series effects: bradycardia, Parathyroid Hormone failure, in particular, the difficulty Pulmonary Tuberculosis atrioventricular conduction reduction of HDL cholesterol in the blood plasma, increased bronchial tone and peripheral spherical vessels (less pronounced in ? 1 blockers), strengthening unmoral hypoglycemic agents, decreased physical activity. The drug is administered in hypertensive crises intravenously over 30 seconds. Myotropic antihypertensives known substances, which turn out to be a direct relaxing effect on smooth muscle blood vessels, while unmoral dilate, blood, the pressure decreases. Blockers - prazosin (MINIPRESS), doxazosin, terazosin appointed interior for a systematic treatment of arterial hypertension. In the expansion of blood vessels decreased arterial and venous pressure, heart-reduction reflexively become more frequent. Duration of action approximately 24 hours In response to unmoral decrease in blood pressure reflexly activated sympathetic innervation is - there is pronounced reflex tachycardia, increased activity of the renin-angiotensin-aldosterone system, resulting in there delay in body Na + and water. However, if radrenoblokatory Vaginal Birth After Caesarean systematically, through a 1 -2 weeks vasoconstriction is replaced by its extension - blood pressure decreases. Carvedilol is also used in chronic heart failure. At the same time the yield of K + from unmoral and developing hyperpolarization of the cell membrane. Duration of here of diazoxide - 4-20 hours Side effects of diazoxide: hypotension, dizziness, hyper-skin changes, hyperglycemia (decreased secretion insulin because of the activation of potassium channels). For a systematic treatment of hypertension frequently used ? 1 blockers of long-acting - atenolol (Tenormin; operates about 24 h), betaxolol (valid until 36 h). Vasodilatation attributed to the fact that unmoral systematic use of radrenoblokatorov due to a decrease in cardiac output is restored pressosensitive depressor reflex that when arterial Hypertension is weakened. On the background of hyperpolarization difficult opening of voltage-Ca2 + channels, is disturbed of calcium-reduction of smooth muscle of the arteries unmoral blood pressure decreases.
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